Ovulation Induction with Pulsatile Gonadotropin-Releasing Hormone (GnRH) and Continuous Human Menopausal Gonadotropin (hMG) in Polycystic Ovarian Disease (PCO)
نویسندگان
چکیده
منابع مشابه
Successful use of pulsatile gonadotropin-releasing hormone (GnRH) for ovulation induction and pregnancy in a patient with GnRH receptor mutations.
GnRH receptor mutations have recently been identified in a small number of familial cases of nonanosmic hypogonadotropic hypogonadism. In the present report we studied a kindred in which two sisters with primary amenorrhea were affected with GnRH deficiency due to a compound heterozygote mutation (Gln(106)Arg, Arg(262)Gln) and performed extensive phenotyping studies. Baseline patterns of gonado...
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Gonadotropin-releasing hormone (GnRH) acts via G-protein-coupled receptors on gonadotrophs to stimulate synthesis and secretion of luteinizing hormone and follicle-stimulating hormone. It is secreted in pulses, and its effects depend on pulse frequency, but decoding mechanisms are unknown. Here we have used an extracellular signal regulated kinase-green fluorescent protein (ERK2-GFP) reporter t...
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The expression of GnRH (GnRH-I, LHRH) and its receptor as a part of an autocrine regulatory system of cell proliferation has been demonstrated in a number of human malignant tumors, including cancers of the ovary. The proliferation of human ovarian cancer cell lines is time- and dose-dependently reduced by GnRH and its superagonistic analogs. The classical GnRH receptor signal-transduction mech...
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We monitored follicular development by ultrasonography on 40 anovulatory women on the day when we switched from HMG to HCG, and measured the maximum follicular diameter (mFD) and the sum total of follicular cross sectional area (FA) and examined the correlations of both mFD and FA with ovulation or OHSS. The ovulatory rate with mFD of more than 18mm was 100%. The correlation coefficients betwee...
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A non-mammalian lamprey-like gonadotropin-releasing hormone (lGnRH) has been detected in human hypothalami using a combination of immunocytochemistry, high performance liquid chromatography and radioimmunoassay. The hypothalamic distribution of immunopositive lGnRH neurons is similar to that observed for those containing the mammalian gonadotropin-releasing hormone (mGnRH), indicating a possibl...
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ژورنال
عنوان ژورنال: Folia Endocrinologica Japonica
سال: 1987
ISSN: 0029-0661
DOI: 10.1507/endocrine1927.63.3_247